The bromophycolides were isolated by the Kubanek laboratory in 2005 (read it here) as a unique family of marine terpenes. Since then the family has been extended to include 18 congeners (read more here). A combination of synthetic and isolation studies were used to map of the antiplasmodial structure–activity relationship (SAR)s of a unique class of macrocyclic meroditerpenes from the red macroalga Callophycus serratus, through collaborative team including Paige Stout, Stefan France and Julia Kubanek at Georgia Tech and Serena Cervantes, Jacques Prudhomme, and Karine Le Roch at UC Riverside (read it here). This SAR map was used to develop fluorescent probes that identified heme crystallization within neutral lipid nanospheres as a mode of action of bromophycolide A. The team is now examining the potential to translate a water soluble analog for clinical application for treatment of drug-resistant Malaria.

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