Ammosamides

We have completed studies on a new family of pyrroloquinolines, the ammosamides A and B, in collaboration with the Fenical laboratory at the Scripps Insitution of Oceanography (structures published here). Using an immunofluorescence affinity (IAF) strategy, Chambers Hughes in the Fenical laboratory prepared an analog of ammosamide B that was then used for both cellular microscopy and protein target indentification studies at XRI to identify myosin as a target of the ammosamides (read it here). This work was subsequently highlighted in Nature Chemical Biology (read it here) and spolighted in ACS Chemical Biology by Eva J. Gordon (read it here).

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